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DKK3 antibody

This anti-DKK3 antibody is a Rabbit Polyclonal antibody detecting DKK3 in WB, ELISA, IHC, ICC and IF. Suitable for Human, Mouse and Rat.
Catalog No. ABIN6261307

Quick Overview for DKK3 antibody (ABIN6261307)

Target

See all DKK3 Antibodies
DKK3

Reactivity

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Human, Mouse, Rat

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This DKK3 antibody is un-conjugated

Application

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
  • Specificity

    DKK3 Antibody detects endogenous levels of total DKK3

    Cross-Reactivity

    Human, Mouse (Murine), Rat (Rattus)

    Purification

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human DKK3

    Isotype

    IgG
  • Application Notes

    WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20 °C.Stable for 12 months from date of receipt

    Expiry Date

    12 months
  • Target

    DKK3

    Background

    Description: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

    Gene: DKK3

    Molecular Weight

    38kDa

    Gene ID

    27122

    UniProt

    Q9UBP4
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