DPP4 antibody (Dipeptidyl-Peptidase 4)

Details for Product anti-DPP4 Antibody No. ABIN6261360
Target
Reactivity
Human, Mouse
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This DPP4 antibody is un-conjugated
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Application
Immunohistochemistry (IHC), Western Blotting (WB)
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Options
Immunogen A synthesized peptide derived from human DPP4.
Isotype IgG
Specificity DPP4 antibody detects endogenous levels of DPP4.
Cross-Reactivity Human, Mouse (Murine)
Purification The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Alternative Name DPP4 (DPP4 Antibody Abstract)
Background

Description: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

Gene: DPP4

Molecular Weight 55-60 kDa
Gene ID 1803
UniProt P27487
Pathways Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity
Application Notes WB 1:500-1:2000, IHC 1:50-1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months
Images
Image no. 1 for anti-Dipeptidyl-Peptidase 4 (DPP4) antibody (ABIN6261360) Western blot analysis of extracts from hepg2, using DPP4 antibody. Lane 1 was treated...
Image no. 2 for anti-Dipeptidyl-Peptidase 4 (DPP4) antibody (ABIN6261360) Western blot analysis of extracts of PC-3 cells, using DPP4 antibody.
Image no. 3 for anti-Dipeptidyl-Peptidase 4 (DPP4) antibody (ABIN6261360) ABIN6273231 at 1/100 staining Human lymph node tissue by IHC-P. The sample was formal...