DPP4 antibody (Dipeptidyl-Peptidase 4) (FITC)

Details for Product anti-DPP4 Antibody No. ABIN457336
Target
Reactivity
Human
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Host
Mouse
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18
9
3
Clonality (Clone)
Monoclonal ()
Conjugate
This DPP4 antibody is conjugated to FITC
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Application
Flow Cytometry (FACS)
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Options
Immunogen A human T cell clone
Clone BA5b
Isotype IgG2a
Specificity The mouse monoclonal antibody BA5b recognizes CD26, a 110 kDa type II membrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells and macrophages.
HLDA VI, WS Code N-L078
Cross-Reactivity (Details) Human
Target
Alternative Name CD26 (DPP4 Antibody Abstract)
Background CD26, also known as dipeptidyl peptidase IV (DPP-IV), is a homodimeric cell surface serine peptidase that degradates IFN-gamma-induced cytokines, acts as a T cell costimulatory molecule, and participates in multiple immunopathological roles in leukocyte homing and inflammation. Alterations in its peptidase activity are characteristic of malignant transformation. The enzymatic activity increases dramatically with tumour grade and severity. CD26 is expressed in various blood cell types, but also e.g. in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
Pathways Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity
Application Notes The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (2 ml) is sufficient for 100 tests.
Comment

The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

Restrictions For Research Use only
Reconstitution No reconstitution is necessary.
Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Avoid prolonged exposure to light.
Storage 4 °C
Storage Comment Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Images
Image no. 1 for anti-Dipeptidyl-Peptidase 4 (DPP4) antibody (FITC) (ABIN457336) Surface staining of human peripheral blood cells with anti-human CD26 (BA5b) FITC.