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Interferon-Induced Transmembrane Protein 3 (IFITM3) antibody Primary Antibody

IFITM3 Reactivity: Human, Mouse, Rat ELISA, ICC, IF, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6262457
$390.77
Plus shipping costs $45.00
100 μL ABIN6262457
100 μL ABIN6262457
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  • Target
    Interferon-Induced Transmembrane Protein 3 (IFITM3)
    Reactivity
    • 38
    • 6
    • 6
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 30
    • 5
    • 3
    Rabbit
    Clonality
    • 34
    • 4
    Polyclonal
    Conjugate
    • 26
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Un-conjugated
    Application
    • 30
    • 19
    • 11
    • 9
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
    Specificity
    IFITM3 Antibody detects endogenous levels of total IFITM3
    Cross-Reactivity
    Human, Mouse (Murine), Rat (Rattus)
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human IFITM3
    Isotype
    IgG
  • Application Notes
    WB 1:1000-3000, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C.Stable for 12 months from date of receipt
    Expiry Date
    12 months
  • Target
    Interferon-Induced Transmembrane Protein 3 (IFITM3)
    Alternative Name
    IFITM3 (IFITM3 Antibody Abstract)
    Synonyms
    1110004C05Rik, Cd225, Cdw217, DSPA2b, Fgls, IP15, mil-1, 1-8U, rat8, Interferon-induced transmembrane protein 3, interferon induced transmembrane protein 3, ifm3, Ifitm3, IFITM3
    Background

    Description: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the  pH in phagocytic endosomes thus establishing an antiviral state.

    Gene: IFITM3

    Molecular Weight
    15 kDa
    Gene ID
    10410
    UniProt
    Q01628
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