Interleukin 17a antibody (Internal Region)

Catalog No. ABIN6262537

Cited in 3+ publications. The Rabbit Polyclonal anti-Interleukin 17a antibody (ABIN6262537) specifically detects Interleukin 17a in ELISA, WB, IHC, IF and ICC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Interleukin 17a antibody (Internal Region) (ABIN6262537)

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Interleukin 17a antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-Interleukin 17a Antibody

Binding Specificity: Internal Region

Specificity: IL17A Antibody detects endogenous levels of total IL17A.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human IL17A, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:200-1:1500, IHC 1:50-1:200, IF/ICC 1:20-1:50, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

References for anti-Interleukin 17a antibody (ABIN6262537)

Zhong, Gao, Zhou, Lin, Chen, Huang, Huang, Zhou, Huang, Nie, Liu, Chen, Zhou, Lv: "Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation." in: Oncotarget, Vol. 8, Issue 25, pp. 40486-40500, (2018) (PubMed).

Wang, Wei, Fan, Ding, Tian, Zhou, Cheng: "Progranulin Is Positively Associated with Intervertebral Disc Degeneration by Interaction with IL-10 and IL-17 Through TNF Pathways." in: Inflammation, (2018) (PubMed).

Yan, Yang, Han, Feng: "Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats." in: Molecular medicine reports, Vol. 14, Issue 2, pp. 1601-9, (2016) (PubMed).

Target Details for Interleukin 17a

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Alternative Name: IL17A

Background:

Description: Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).

Gene: IL17A

Molecular Weight: 18kDa

Gene ID: 3605

UniProt: Q16552