KCNMB3 antibody (N-Term)

Catalog No. ABIN6262755

The Rabbit Polyclonal anti-KCNMB3 antibody is suitable to detect KCNMB3 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for KCNMB3 antibody (N-Term) (ABIN6262755)

Target: KCNMB3 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M beta Member 3 (KCNMB3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNMB3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-KCNMB3 Antibody

Binding Specificity: N-Term

Specificity: KCNMB3 Antibody detects endogenous levels of total KCNMB3.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human KCNMB3, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for KCNMB3

Target: KCNMB3 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M beta Member 3 (KCNMB3))

Alternative Name: KCNMB3

Background:

Description: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.

Gene: KCNMB3

Molecular Weight: 32 kDa

Gene ID: 27094

UniProt: Q9NPA1