STAMBP antibody (C-Term)

Catalog No. ABIN6265307

This Rabbit Polyclonal antibody specifically detects STAMBP in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for STAMBP antibody (C-Term) (ABIN6265307)

Target: STAMBP (STAM Binding Protein (STAMBP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAMBP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-STAMBP Antibody

Binding Specificity: C-Term

Specificity: STAMBP Antibody detects endogenous levels of total STAMBP.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human STAMBP, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for STAMBP

Target: STAMBP (STAM Binding Protein (STAMBP))

Alternative Name: STAMBP

Background:

Description: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.

Gene: STAMBP

Molecular Weight: 50 kDa

Gene ID: 10617

UniProt: O95630