TRIM14 antibody (C-Term)

Catalog No. ABIN6265727

This Rabbit Polyclonal antibody specifically detects TRIM14 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for TRIM14 antibody (C-Term) (ABIN6265727)

Target: TRIM14 (Tripartite Motif Containing 14 (TRIM14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM14 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TRIM14 Antibody

Binding Specificity: C-Term

Specificity: TRIM14 Antibody detects endogenous levels of total TRIM14.

Predicted Reactivity: Pig,Bovine,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TRIM14, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for TRIM14

Target: TRIM14 (Tripartite Motif Containing 14 (TRIM14))

Alternative Name: TRIM14

Background:

Description: Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373). Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593).

Gene: TRIM14

Molecular Weight: 50 kDa

Gene ID: 9830

UniProt: Q14142