USP34 antibody (N-Term)

Catalog No. ABIN6265924

This anti-USP34 antibody is a Rabbit Polyclonal antibody detecting USP34 in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for USP34 antibody (N-Term) (ABIN6265924)

Target: USP34 (Ubiquitin Specific Peptidase 34 (USP34))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP34 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-USP34 Antibody

Binding Specificity: N-Term

Specificity: USP34 Antibody detects endogenous levels of total USP34.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human USP34, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for USP34

Target: USP34 (Ubiquitin Specific Peptidase 34 (USP34))

Alternative Name: USP34

Background:

Description: Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

Gene: USP34

Molecular Weight: 404 kDa

Gene ID: 9736

UniProt: Q70CQ2