ZBTB17 antibody (Internal Region)

Catalog No. ABIN6266089

The Rabbit Polyclonal anti-ZBTB17 antibody (ABIN6266089) specifically detects ZBTB17 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ZBTB17 antibody (Internal Region) (ABIN6266089)

Target: ZBTB17 (Zinc Finger and BTB Domain Containing 17 (ZBTB17))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZBTB17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ZBTB17 Antibody

Binding Specificity: Internal Region

Specificity: ZBTB17 Antibody detects endogenous levels of total ZBTB17.

Predicted Reactivity: Pig,Bovine,Horse,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ZBTB17, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ZBTB17

Target: ZBTB17 (Zinc Finger and BTB Domain Containing 17 (ZBTB17))

Alternative Name: ZBTB17

Background:

Description: Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription, this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).

Gene: ZBTB17

Molecular Weight: 88 kDa

Gene ID: 7709

UniProt: Q13105

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, ER-Nucleus Signaling