POMC antibody (AA 1-24)

Catalog No. ABIN6294239

The Mouse Monoclonal anti-POMC antibody has been validated for ELISA, IHC, FACS, IF and Coat. It is suitable to detect POMC in samples from Human, Mouse and Rat.

Quick Overview for POMC antibody (AA 1-24) (ABIN6294239)

Target: POMC (Proopiomelanocortin (POMC))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This POMC antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Coating (Coat)

Product Details anti-POMC Antibody

Binding Specificity: AA 1-24

Purpose: Mouse anti-Human/Mouse/Rat ACTH Antibody [Sodium Azide Free]

Specificity: Cytoplasmic

Purification: A synthetic peptide corresponding to aa 1-24 of human ACTH was used as the immunogen for this antibody.

Immunogen: A synthetic peptide corresponding to aa 1-24 of human ACTH was used as the immunogen for this antibody.

Application Details

Application Notes: ELISA: order BSA-free format for coating
FACS: 0.5-1 μg/million cells
IF: 0.5-1 μg/mL
IHC (FFPE): 0.5-1.0 μg/mL for 30 minutes at RT (1)

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for POMC

Target: POMC (Proopiomelanocortin (POMC))

Alternative Name: Pro-opiomelanocortin , Beta-endorphin, Met-enkephalin]

Background:

Target Description: POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific post-translational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH (also called Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This antibody is specific to Synacthen (aa 1-24 of ACTH) and does not react with CLIP (aa 17-39 of ACTH). ACTH is produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. ACTH antibody is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

Gene Symbol: POMC

Gene ID: 5443

UniProt: P01189

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour