ANO1 antibody (AA 904-986)

Catalog No. ABIN6294608

The Mouse Monoclonal anti-ANO1 antibody has been validated for IHC. It is suitable to detect ANO1 in samples from Human.

Quick Overview for ANO1 antibody (AA 904-986) (ABIN6294608)

Target: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ANO1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-ANO1 Antibody

Binding Specificity: AA 904-986

Purpose: Mouse anti-Human DOG-1 Antibody [IHC only]

Specificity: Cell Surface and Cytoplasm

Purification: Amino acids 904-986 from the human protein was used as the immunogen for this DOG-1 antibody.

Immunogen: Amino acids 904-986 from the human protein was used as the immunogen for this DOG-1 antibody.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for ANO1

Target: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Alternative Name: Anoctamin-1

Background:

Target Description: Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4 % vs. 94.7 %.

Gene Symbol: ANO1///DOG1///ORAOV2///TAOS2///TMEM16A

Gene ID: 55107

UniProt: Q5XXA6