VLDLR antibody (C-Term)

Catalog No. ABIN6294641

The Mouse Monoclonal anti-VLDLR antibody has been validated for WB, IHC, FACS and IF. It is suitable to detect VLDLR in samples from Human and Rat.

Quick Overview for VLDLR antibody (C-Term) (ABIN6294641)

Target: VLDLR (Very Low Density Lipoprotein Receptor (VLDLR))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This VLDLR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-VLDLR Antibody

Binding Specificity: C-Term

Purpose: Mouse anti-Human/Rat VLDLR Antibody [Sodium Azide Free]

Specificity: Cytoplasmic

Purification: A human partial recombinant protein from the C-terminal region was used as the immunogen for this VLDLR antibody.

Immunogen: A human partial recombinant protein from the C-terminal region was used as the immunogen for this VLDLR antibody.

Application Details

Application Notes: FACS: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL
Western blot: 1-2 μg/mL
IHC (FFPE): 1-2 μg/mL (1)

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for VLDLR

Target: VLDLR (Very Low Density Lipoprotein Receptor (VLDLR))

Alternative Name: Very low-density lipoprotein receptor

Background:

Target Description: Very Low Density Lipoprotein Receptor (VLDLR/VLDL receptor) is a member of the LDL receptor gene family which includes LDL receptor, LRP, megalin, VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR associates with RAP (receptor associated protein) during receptor folding, and RAP facilitates the secretion of the extracellular region of VLDLR. VLDL receptor is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development.

Gene Symbol: VLDLR

Gene ID: 7436

UniProt: P98155

Pathways: Cellular Response to Molecule of Bacterial Origin