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GNRHR antibody (N-Term)

This anti-GNRHR antibody is a Mouse Monoclonal antibody detecting GNRHR in IF, FACS and IHC. Suitable for Human and Rat.
Catalog No. ABIN6295521

Quick Overview for GNRHR antibody (N-Term) (ABIN6295521)

Target

See all GNRHR Antibodies
GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Reactivity

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Human, Rat

Host

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Mouse

Clonality

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Monoclonal

Conjugate

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This GNRHR antibody is un-conjugated

Application

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Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC)
  • Binding Specificity

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    AA 1-29, N-Term

    Purpose

    Mouse anti-Human/Rat GnRH Receptor Antibody [Sodium Azide Free]

    Specificity

    Cytoplasmic

    Purification

    A synthetic peptide aa 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRHR was used as the immunogen for the GnRH Receptor antibody.

    Immunogen

    A synthetic peptide aa 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRHR was used as the immunogen for the GnRH Receptor antibody.
  • Application Notes

    Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
    Immunofluorescence: 1-2 μg/mL
    Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT (1)
    Prediluted format: incubate for 30 min at RT (2)

    Restrictions

    For Research Use only
  • Buffer

    In 1X PBS, BSA free, sodium azide free

    Preservative

    Azide free

    Storage

    4 °C,-20 °C

    Storage Comment

    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • Target

    GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

    Alternative Name

    Gonadotropin-releasing hormone receptor

    Background

    Target Description: Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.

    Gene Symbol: GNRHR///GRHR

    Gene ID

    2798

    UniProt

    P30968
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