TNFSF15 antibody

Catalog No. ABIN6295967

The Mouse Monoclonal anti-TNFSF15 antibody has been validated for WB, IHC, IF and FACS. It is suitable to detect TNFSF15 in samples from Human.

Quick Overview for TNFSF15 antibody (ABIN6295967)

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFSF15 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-TNFSF15 Antibody

Purpose: Mouse anti-Human VEGI / TL1A Antibody [Sodium Azide Free]

Specificity: Cytoplasmic, cell surface, secreted

Purification: A full length human recombinant protein was used as the immunogen for this TL1A antibody.

Immunogen: A full length human recombinant protein was used as the immunogen for this TL1A antibody.

Application Details

Application Notes: FACS: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL
Western blot: 1-2 μg/mL
IHC (FFPE): 1-2 μg/mL

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for TNFSF15

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Alternative Name: Tumor necrosis factor ligand superfamily member 15

Background:

Target Description: TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A has been reported as a marker of poor prognosis in breast cancer.

Gene Symbol: TNFSF15///TL1///VEGI

Gene ID: 9966

UniProt: O95150

Pathways: Positive Regulation of Endopeptidase Activity, Autophagy