Fibronectin antibody

Catalog No. ABIN6296126

The Mouse Monoclonal anti-Fibronectin antibody has been validated for IHC, IF and FACS. It is suitable to detect Fibronectin in samples from Human, Rat, Mouse and Pig.

Quick Overview for Fibronectin antibody (ABIN6296126)

Target: Fibronectin

Reactivity: Human, Rat, Mouse, Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: This Fibronectin antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-Fibronectin Antibody

Purpose: Mouse anti-Human/Pig/Mouse/Rat Fibronectin Antibody [Sodium Azide Free]

Specificity: Connective tissue matrix

Purification: A T-cell lymphoma biopsy was used as the immunogen for this fibronectin antibody.

Immunogen: A T-cell lymphoma biopsy was used as the immunogen for this fibronectin antibody.

Application Details

Application Notes: FACS: 0.5-1 μg/million cells
IF: 0.5-1 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for Fibronectin

Target: Fibronectin

Background:

Target Description: Fibronectin is a soluble dimeric glycoprotein of 440 kDa, which is present in cells, extracellular matrix, and blood. There are two types of fibronectin: soluble fibronectin which is produced by hepatocytes and found in blood plasma, and insoluble cellular fibronectin which is produced by fibroblasts in a soluble form and latter assembled into an insoluble form via fibril formation.This antibody reacts with the cellular as well as plasma form of fibronectin. Reportedly, after iv administration, this antibody localizes to tumor vessels where it binds to the underlying basement. The Fibronectin epitope recognized by this antibody is not accessible in normal tissues to the circulating antibody indicating that it can be used to specifically target tumor vessels in vivo. Clone TV-1 fibronectin antibody is reportedly useful for delivering vasoactive agents to tumors to induce increased vascular permeability or blood flow prior to treatment with chemotherapeutic drugs or antibodies.

Gene Symbol: FN1///FN

Gene ID: 2335

UniProt: P02751