VCAM1 antibody

Catalog No. ABIN6296140

This Mouse Monoclonal antibody specifically detects VCAM1 in FACS, IF, Func and BP. It exhibits reactivity toward Human.

Quick Overview for VCAM1 antibody (ABIN6296140)

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This VCAM1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func), Blocking Peptide (BP)

Product Details anti-VCAM1 Antibody

Purpose: Mouse anti-Human VCAM1 Antibody [Sodium Azide Free]

Specificity: Cytoplasmic, membrane

Purification: Activated human umbilical vein endothelial cells (HUVEC) were used as the immunogen for the VCAM1 antibody.

Immunogen: Activated human umbilical vein endothelial cells (HUVEC) were used as the immunogen for the VCAM1 antibody.

Application Details

Application Notes: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Functional blocking: order BSA/azide free format

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for VCAM1

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Alternative Name: Vascular cell adhesion protein 1

Background:

Target Description: Recognizes a protein of 110 kDa, identified as CD106 (also known as vascular cell adhesion molecule-1 (VCAM-1), L1CAM and INCAM-100). It is a member of the Ig superfamily of adhesion molecules and is expressed at high levels on cytokine stimulated vascular endothelial cells, and at minimal levels on un-stimulated endothelial cells. It is also present on follicular and inter-follicular dendritic cells of lymph nodes, myoblasts, and some macrophages. L1CAM serves as a ligand for leukocyte integrin (VLA-4 or CD49d/CD29) and mediates cell adhesion of leukocytes to activated endothelium. It plays a role in various immunological and inflammatory responses. This mAb inhibits the binding of leukocytes to L1CAM on stimulated endothelial cells.

Gene Symbol: VCAM1

Gene ID: 7412

UniProt: P19320

Pathways: Carbohydrate Homeostasis