Fascin antibody

Catalog No. ABIN6296304

This anti-Fascin antibody is a Mouse Monoclonal antibody detecting Fascin in IHC, FACS and IF. Suitable for Human and Rat.

Quick Overview for Fascin antibody (ABIN6296304)

Target: Fascin (FSCN1)

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Fascin antibody is un-conjugated

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-Fascin Antibody

Purpose: Mouse anti-Human/Rat Fascin Antibody [Sodium Azide Free]

Specificity: Cytoplasmic

Purification: Full length recombinant human protein was used as the immunogen for the Fascin antibody.

Immunogen: Full length recombinant human protein was used as the immunogen for the Fascin antibody.

Application Details

Application Notes: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistology (FFPE): 0.5-1.0 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for Fascin

Target: Fascin (FSCN1)

Alternative Name: Fascin

Background:

Target Description: Fascin/FSCN1 binds beta-catenin and colocalizes with it at the leading edges and borders of epithelial and endothelial cells. The role of FSCN1 in regulating cytoskeletal structures for the maintenance of cell adhesion, coordinating motility and invasion through interactions with signalling pathways is an active area of research especially from the cancer biology perspective. It localizes to actin-rich protrusions at the cell surface called filopodia. FSCN1 localizes to invadopodia, membrane protrusions formed at the adherent cell surface that facilitate extracellular matrix (ECM) invasion, this provide a potential molecular mechanism for how fascin increases the invasiveness of cancer cells since fascin expression is upregulated in a spectrum of cancers. [Wiki]

Gene Symbol: FSCN1///FAN1///HSN///SNL

Gene ID: 6624

UniProt: Q16658