P24 Capsid Protein antibody

Catalog No. ABIN6297130

This Mouse Monoclonal antibody specifically detects P24 Capsid Protein in Coat, ELISA, ICC and IF. It exhibits reactivity toward Human.

Quick Overview for P24 Capsid Protein antibody (ABIN6297130)

Target: P24 Capsid Protein

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Application: Coating (Coat), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details

Purpose: Mouse anti-Human HIV Type-1 p24 Antibody [Sodium Azide Free]

Specificity: Membrane

Purification: Recombinant HIV-1 Gag p24 protein was used as the immunogen for this antibody.

Immunogen: Recombinant HIV-1 Gag p24 protein was used as the immunogen for this antibody.

Application Details

Application Notes: ELISA: order BSA-free format for coating
Immunocytochemistry (Acetone or paraformaldehyde fixed): 0.5-1 μg/mL for 30 min
IF: 0.5-1 μg/mL,

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details

Target: P24 Capsid Protein

Alternative Name: Capsid protein p24 ]

Target Type: Viral Protein

Background:

Target Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

Gene Symbol: gag-pol

Gene ID: 155348

UniProt: P04585