BAFF antibody

Catalog No. ABIN6297137

The Mouse Monoclonal anti-BAFF antibody has been validated for FACS and IF. It is suitable to detect BAFF in samples from Human.

Quick Overview for BAFF antibody (ABIN6297137)

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BAFF antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-BAFF Antibody

Purpose: Mouse anti-Human BAFF Antibody / BLyS [Sodium Azide Free]

Specificity: Cell surface, cytoplasmic

Purification: Recombinant human BAFF protein was used as the immunogen for this BAFF antibody.

Immunogen: Recombinant human BAFF protein was used as the immunogen for this BAFF antibody.

Application Details

Application Notes: FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL

Restrictions: For Research Use only

Handling

Buffer: In sterile PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for BAFF

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Alternative Name: Tumor necrosis factor ligand superfamily member 13B

Background:

Target Description: BAFF/BLyS/CD257 is a type II transmembrane protein, and a member of the tumor necrosis factor ligand superfamily. It is proteolytically cleaved to form a soluble protein. BAFF, like other TNF ligand family members, forms homo-trimers. The predicted molecular weight of a BAFF monomer is approximately 31 kDa. It is expressed on peripheral blood B and T lymphocytes, monocytes, macrophages, and dendritic cells and is upregulated by IFN-gamma and down-regulated by PMA/ionomycin treatment. BAFF stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors, BAFF prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3).

Gene Symbol: TNFSF13B///BAFF///BLYS///TALL1///TNFSF20///ZTNF4///UNQ401///PRO738

Gene ID: 10673

UniProt: Q9Y275

Pathways: NF-kappaB Signaling, Production of Molecular Mediator of Immune Response