RNMT antibody

Details for Product No. ABIN6297574
Target
Reactivity
Cow, Dog, Human, Rat
15
9
8
8
4
4
3
3
2
2
1
1
Host
Mouse
8
7
Clonality
Monoclonal
Application
Immunohistochemistry (IHC)
11
8
7
4
3
2
Options
Purpose Mouse anti-Human/Cow/Dog/Rat TAG-72 Antibody [IHC only]
Immunogen Recombinant human TAG-72 protein was used as the immunogen for this antibody.
Specificity Cytoplasmic and cell surface
Purification Recombinant human TAG-72 protein was used as the immunogen for this antibody.
Target
Alternative Name mRNA cap guanine-N7 methyltransferase  
Background

Target Description: This antibody recognizes an oncofetal antigen of 220 kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. This antibody defines the mucin-carried sialylated-Tn epitope. TAG-72 is usually expressed by adenocarcinomas, but is negative in mesotheliomas. Studies have reported that this antibody has 80 % sensitivity and 93 % specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur so results must be interpreted with the utmost caution. This antibody may be useful in the differentiation of non-small cell carcinomas from small cell carcinomas of the lung. The combined use of TAG-72 antibody with a GCDFP-15 antibody is valuable in the diagnosis of apocrine carcinoma.

Gene Symbol: tag-72  C25A1.3

Gene ID 182875
UniProt Q9XVS1
Application Notes Prediluted format : incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.