p53 antibody (Tumor Protein P53)

Details for Product anti-TP53 Antibody No. ABIN6297587
Antigen
  • BCC7
  • LFS1
  • P53
  • TRP53
  • p53
  • Trp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • tp53
  • Xp53
  • TP53
  • tumor protein p53
  • cellular tumor antigen p53
  • transformation related protein 53
  • tumor protein p53 L homeolog
  • TP53
  • CpipJ_CPIJ002758
  • Tp53
  • tp53
  • Trp53
  • tp53.L
Reactivity
Cow (Bovine), Human, Monkey
2275
501
482
271
101
76
72
38
25
22
20
15
14
7
6
5
4
4
4
4
3
3
3
3
2
2
1
1
1
Host
Mouse
1627
713
7
5
1
1
1
1
Clonality
Monoclonal
Conjugate
This p53 antibody is un-conjugated
84
55
45
41
40
40
40
39
39
32
29
28
12
12
12
12
11
10
8
7
7
7
7
7
7
7
7
7
7
7
7
7
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
1815
762
749
573
419
393
293
155
109
100
67
55
41
41
32
28
20
19
15
15
6
3
3
2
2
2
1
1
1
1
1
1
1
1
Options
Purpose Mouse anti-Human/Monkey/Cow p53 Antibody Cocktail [IHC only]
Immunogen Recombinant human wild-type p53 protein (BP53-12) & Recombinant human wild type p53 protein expressed in E. coli (DO-7) were used as the immunogen for this antibody cocktail.
Specificity Nuclear
Purification Recombinant human wild-type p53 protein (BP53-12) & Recombinant human wild type p53 protein expressed in E. coli (DO-7) were used as the immunogen for this antibody cocktail.
Plasmids, Primers & others Plasmids, Primers & others p53 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Cellular tumor antigen p53 (TP53 Antibody Abstract)
Background

Target Description: This antibody cocktail is specific for a 53 kDa protein, which is identified as p53 suppressor gene product. The antibody cocktail reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. antibody to p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Gene Symbol: TP53///P53

Gene ID 7157
UniProt P04637
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy
Application Notes Prediluted format : incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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