PCNA antibody (Proliferating Cell Nuclear Antigen)

Details for Product anti-PCNA Antibody No. ABIN6297605
Antigen
  • PCNAR
  • Pcna/cyclin
  • pcna
  • AO090003000846
  • 53/13
  • CG9193
  • DmPCNA
  • Dmel\\CG9193
  • MUS209
  • Mus209
  • PCNA
  • PCNA/mus209
  • Pcna
  • dPCNA
  • l(2)02448
  • l(2)56F
  • l(2)56Fa
  • l(2)s1534
  • cb16
  • fb36g03
  • wu:fa28e03
  • wu:fb36g03
  • pcna-A
  • proliferating cell nuclear antigen
  • DNA polymerase III sliding clamp
  • Proliferating cell nuclear antigen
  • Proliferating cell nuclear antigen-like
  • proliferating cell nuclear antigen L homeolog
  • proliferating cell nuclear antigen 1
  • PCNA
  • Pcna
  • pcna
  • MMP_RS08810
  • ANI_1_512014
  • AOR_1_1500154
  • MGC53867
  • pcna.L
  • pcna1
  • LOC106420145
  • pcn1
Reactivity
Human
508
273
257
63
51
45
43
38
37
26
22
18
12
12
11
8
7
5
5
4
4
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
Host
Mouse
301
237
4
2
Clonality
Monoclonal
Conjugate
This PCNA antibody is un-conjugated
24
19
11
8
8
8
8
8
8
6
4
4
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
410
191
122
121
118
108
77
53
44
34
21
11
10
7
7
4
3
3
1
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Options
Purpose Mouse anti-Human PCNA Antibody [Sodium Azide Free]
Immunogen Recombinant proliferating cell nuclear antigen was used as the immunogen for the PCNA antibody.
Specificity Nuclear with some cytoplasmic
Purification Recombinant proliferating cell nuclear antigen was used as the immunogen for the PCNA antibody.
Plasmids, Primers & others Plasmids, Primers & others PCNA products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Proliferating cell nuclear antigen (PCNA Antibody Abstract)
Background

Target Description: Proliferating cell nuclear antigen is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. [UniProt]

Gene Symbol: PCNA

Gene ID 5111
UniProt P12004
Pathways Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagy
Application Notes Western blot: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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