PCNA antibody
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- Target See all PCNA Antibodies
- PCNA (Proliferating Cell Nuclear Antigen (PCNA))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This PCNA antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purpose
- Mouse anti-Human PCNA Antibody [Sodium Azide Free]
- Specificity
- Nuclear with some cytoplasmic
- Purification
- Recombinant proliferating cell nuclear antigen was used as the immunogen for the PCNA antibody.
- Immunogen
- Recombinant proliferating cell nuclear antigen was used as the immunogen for the PCNA antibody.
- Top Product
- Discover our top product PCNA Primary Antibody
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anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 151-261) antibody
PCNA Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 231-261), (C-Term) antibodyPCNA Reactivity: Human WB, IF, IHC (p) Host: Rabbit Polyclonal RB17486 unconjugated
anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 53-196) antibodyPCNA Reactivity: Human WB, IHC, ELISA, FACS Host: Mouse Monoclonal 7H4F8 unconjugated
anti-Proliferating Cell Nuclear Antigen (PCNA) antibodyPCNA Reactivity: Human WB, IHC, IF, IHC (p), IP, ICC, IHC (fro), FISH Host: Rabbit Polyclonal unconjugated
anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 1-261) antibodyPCNA Reactivity: Human WB, ELISA, IF, IP Host: Mouse Monoclonal 1G7 unconjugated
anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 1-261) antibodyPCNA Reactivity: Human WB, ELISA Host: Mouse Monoclonal S1 unconjugated
anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 1-261) antibodyPCNA Reactivity: Human WB, IHC, IF, IP Host: Rabbit Polyclonal unconjugated
anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 201-261) antibodyPCNA Reactivity: Human, Mouse, Rat, Chicken WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 6-261) antibodyPCNA Reactivity: Human, Mouse, Rat, Pig, Rabbit, Dog, Rhesus Monkey WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Proliferating Cell Nuclear Antigen (PCNA) antibodyPCNA Reactivity: Human WB, IHC, IHC (p) Host: Mouse Monoclonal 1H10 unconjugated
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- Application Notes
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Western blot: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2) - Restrictions
- For Research Use only
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- Buffer
- In 1X PBS, BSA free, sodium azide free
- Preservative
- Azide free
- Storage
- 4 °C,-20 °C
- Storage Comment
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Target
- PCNA (Proliferating Cell Nuclear Antigen (PCNA))
- Alternative Name
- Proliferating cell nuclear antigen (PCNA Products)
- Background
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Target Description: Proliferating cell nuclear antigen is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. [UniProt]
Gene Symbol: PCNA
- Gene ID
- 5111
- UniProt
- P12004
- Pathways
- Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagy
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