CD27 antibody

Catalog No. ABIN6297638

The Mouse Monoclonal anti-CD27 antibody has been validated for FACS and IF. It is suitable to detect CD27 in samples from Human.

Quick Overview for CD27 antibody (ABIN6297638)

Target: CD27 (CD27 Molecule (CD27))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD27 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-CD27 Antibody

Purpose: Mouse anti-Human CD27 Antibody [Sodium Azide Free]

Specificity: Cell surface

Purification: Sezary cells were used as the immunogen for the CD27 antibody.

Immunogen: Sezary cells were used as the immunogen for the CD27 antibody.

Application Details

Application Notes: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for CD27

Target: CD27 (CD27 Molecule (CD27))

Alternative Name: CD27 antigen

Background:

Target Description: Recognizes a protein of a disulfide-linked 120 kDa dimer, identified as CD27 (Workshop VI, Code 6T-028). CD27 is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NFB and SAPK/JNK and induces apoptosis.

Gene Symbol: CD27///TNFRSF7

Gene ID: 939

UniProt: P26842

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints