CD45 antibody (Protein tyrosine Phosphatase, Receptor Type, C)

Details for Product anti-PTPRC Antibody No. ABIN6297670
Antigen
  • PTPRC
  • si:dkeyp-47c5.1
  • B220
  • CD45
  • CD45R
  • GP180
  • L-CA
  • LCA
  • LY5
  • T200
  • Cd45
  • Ly-5
  • Lyt-4
  • loc
  • Lca
  • RT7
  • cd45
  • protein tyrosine phosphatase, receptor type C
  • protein tyrosine phosphatase, receptor type, C
  • receptor-type tyrosine-protein phosphatase C
  • PTPRC
  • ptprc
  • LOC100074271
  • Ptprc
Reactivity
Human
1292
559
144
82
52
41
36
29
19
14
13
13
9
8
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5
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3
3
2
1
1
1
1
Host
Mouse
1210
540
291
3
2
Clonality
Monoclonal
Conjugate
This CD45 antibody is un-conjugated
241
215
140
130
53
25
24
23
23
23
22
21
17
15
15
11
11
10
10
10
9
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4
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3
3
2
2
2
2
2
1
1
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1
1
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Application
Immunohistochemistry (IHC)
1682
639
450
405
324
265
207
114
76
74
52
37
32
16
8
4
4
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3
3
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Options
Purpose Mouse anti-Human CD45RA Antibody [IHC only]
Immunogen Stimulated human leukocytes were used as immunogen for this CD45RA antibody.
Specificity Cell surface
Purification Stimulated human leukocytes were used as immunogen for this CD45RA antibody.
Plasmids, Primers & others Plasmids, Primers & others CD45 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Receptor-type tyrosine-protein phosphatase C (PTPRC Antibody Abstract)
Background

Target Description: CD45RA is an isoform of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50 % of peripheral CD4+ T-cells, 50 % of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

Gene Symbol: PTPRC///CD45

Gene ID 5788
UniProt P08575
Pathways TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events
Application Notes Prediluted format : incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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