CD45 antibody (Protein tyrosine Phosphatase, Receptor Type, C)

Details for Product anti-PTPRC Antibody No. ABIN6297700
Antigen
  • PTPRC
  • si:dkeyp-47c5.1
  • B220
  • CD45
  • CD45R
  • GP180
  • L-CA
  • LCA
  • LY5
  • T200
  • Cd45
  • Ly-5
  • Lyt-4
  • loc
  • Lca
  • RT7
  • cd45
  • protein tyrosine phosphatase, receptor type C
  • protein tyrosine phosphatase, receptor type, C
  • receptor-type tyrosine-protein phosphatase C
  • PTPRC
  • ptprc
  • LOC100074271
  • Ptprc
Reactivity
Human
1294
559
144
82
52
41
36
29
19
14
13
13
9
8
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5
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3
3
2
1
1
1
1
Host
Mouse
1212
540
291
3
2
Clonality
Monoclonal
Conjugate
This CD45 antibody is un-conjugated
241
215
141
130
53
25
24
23
23
23
22
21
17
15
15
11
11
10
10
10
9
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7
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7
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7
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4
4
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3
3
2
2
2
2
2
1
1
1
1
1
1
1
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Application
Immunohistochemistry (IHC)
1684
639
450
405
324
265
207
114
76
74
52
37
32
16
8
4
4
3
3
3
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Options
Purpose Mouse anti-Human CD45RA Antibody [IHC only]
Immunogen Stimulated human leukocytes were used as the immunogen for this CD45RA antibody.
Specificity Cell surface
Purification Stimulated human leukocytes were used as the immunogen for this CD45RA antibody.
Plasmids, Primers & others Plasmids, Primers & others CD45 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Receptor-type tyrosine-protein phosphatase C (PTPRC Antibody Abstract)
Background

Target Description: This antibody recognizes a protein of 205 kDa-220 kDa, identified as CD45RA, an isoform of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50 % of peripheral CD4+ Tcells, 50 % of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin Tcells. T-cells expressing CD45RO are memory Tcells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral Tcells. This CD45RA antibody is useful in the study of the subpopulation of CD4+ or CD8+ T-cells. It is especially useful in differentiating T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

Gene Symbol: PTPRC///CD45

Gene ID 5788
UniProt P08575
Pathways TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events
Application Notes Prediluted format : incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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