Thyroglobulin antibody

Catalog No. ABIN6297748

This Mouse Monoclonal antibody specifically detects Thyroglobulin in IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Thyroglobulin antibody (ABIN6297748)

Target: Thyroglobulin (TG)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Thyroglobulin antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Thyroglobulin Antibody

Purpose: Mouse anti-Human/Mouse/Rat Thyroglobulin Antibody [IHC only]

Specificity: Cytoplasmic and secreted

Purification: The immunogen for this Thyroglobulin antibody was human thyroid epithelial cells.

Immunogen: The immunogen for this Thyroglobulin antibody was human thyroid epithelial cells.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for Thyroglobulin

Target: Thyroglobulin (TG)

Alternative Name: Thyroglobulin

Background:

Target Description: Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq]

Gene Symbol: TG

Gene ID: 7038

UniProt: P01266

Pathways: Thyroid Hormone Synthesis