RNMT antibody

Details for Product No. ABIN6297753
Antigen
  • xCMT1
  • MET
  • RG7MT1
  • hCMT1c
  • 2610002P10Rik
  • AI848273
  • Rg7mt1
  • mKIAA0398
  • rnmt
  • im:6910566
  • wu:fi09c12
  • RNA (guanine-7-) methyltransferase L homeolog
  • RNA guanine-7 methyltransferase
  • RNA (guanine-7-) methyltransferase
  • rnmt.L
  • RNMT
  • Rnmt
  • rnmt
Reactivity
Cow (Bovine), Dog (Canine), Human, Rat (Rattus)
33
22
14
14
12
4
3
3
3
2
1
1
Host
Mouse
18
16
Clonality
Monoclonal
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
23
19
15
8
8
2
1
1
Options
Purpose Mouse anti-Human/Cow/Dog/Rat TAG-72 Antibody Cocktail [Sodium Azide Free]
Immunogen The membrane-enriched fraction of a human breast carcinoma liver metastasis (B72.3) and TAG-72 protein (CA72/733) were used as the immunogens for this antibody cocktail.
Specificity Cytoplasmic and cell surface
Purification The membrane-enriched fraction of a human breast carcinoma liver metastasis (B72.3) and TAG-72 protein (CA72/733) were used as the immunogens for this antibody cocktail.
Antigen
Alternative Name mRNA cap guanine-N7 methyltransferase  
Background

Target Description: This antibody recognizes an oncofetal antigen of 220 kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. This antibody defines the mucin-carried sialylated-Tn epitope. TAG-72 is usually expressed by adenocarcinomas, but is negative in mesotheliomas. Studies have reported that this antibody has 80 % sensitivity and 93 % specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur so results must be interpreted with the utmost caution. This antibody may be useful in the differentiation of non-small cell carcinomas from small cell carcinomas of the lung. The combined use of TAG-72 antibody with a GCDFP-15 antibody is valuable in the diagnosis of apocrine carcinoma.

Gene Symbol: tag-72  C25A1.3

Gene ID 182875
UniProt Q9XVS1
Application Notes FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer In 1X PBS ( pH 7.4), BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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