STAT2 antibody (Biotin)

Catalog No. ABIN6297844

Product Details anti-STAT2 Antibody (Biotin)

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT2 antibody is conjugated to Biotin

Application: ELISA

Purpose: Rabbit anti-Human Phosphorylated STAT2 Antibody [+Biotin],

Immunogen: This antibody was produced from antiserum of rabbits immunized with a synthetic immunogen. The IgG fraction was purified by Protein A affinity chromatography.

Application Details

Application Notes: ELISA (recommended work dilution= 1:320,000)

Restrictions: For Research Use only

Handling

Reconstitution: Product is supplied as a powder obtained from lyophilization of purified antibody in citric acid solution . Reconstitute the antibody with diluent buffer to a final concentration of 1 mg/mL.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: -20°C

Target Details for STAT2

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Alternative Name: Signal transducer and activator of transcription 2 (STAT2 Products)

Synonyms: wu:fj84d07 antibody, p113 antibody, stat2 antibody, 1600010G07Rik antibody, AW496480 antibody, ISGF-3 antibody, P113 antibody, STAT113 antibody, signal transducer and activator of transcription 2 antibody, AGAP000099-PA antibody, stat2 antibody, STAT2 antibody, Stat2 antibody

Background:

Target Description: Signal transducer and activator of transcription 2  is a  protein  that in humans is encoded by the STAT2  gene.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.STAT2-PY is the phosphorylated form of STAT2 protein.

Gene Symbol: STAT2

Gene ID: 6773

UniProt: P52630

Pathways: JAK-STAT Signaling, Hepatitis C, CXCR4-mediated Signaling Events