Adipolean (Variant) antibody
Reactivity: Human
ELISA, WB, Inhibition
Host: Rabbit
Polyclonal
unconjugated
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- Target
- Adipolean
- Binding Specificity
- Variant
- Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
- Application
- ELISA, Western Blotting (WB), Blocking Antibody (Inhibition)
- Purification
- Purified
- Immunogen
- Adipolean Variant antibody was raised in rabbit using highly pure recombinant human adipolean variant as the immunogen.
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- Application Notes
- Optimal conditions should be determined byt he investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized from PBS, pH 7.2.
- Handling Advice
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. - Storage
- 4 °C/-20 °C
- Storage Comment
- Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.
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- Target
- Adipolean
- Background
- The adipolean variant is an important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. It stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. The adipolean variant antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It also inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway.
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