PDE8B antibody

Catalog No. ABIN636941

The Rabbit Polyclonal anti-PDE8B antibody is suitable to detect PDE8B in samples from Human. It has been validated for IHC (p).

Quick Overview for PDE8B antibody (ABIN636941)

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8B antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PDE8B Antibody

Purification: Affinity chromatography purified

Immunogen: PDE8 B antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.

Application Details

Application Notes: IHC-P: 10 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1 % NaN3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -70 °C for long term storage.

Target Details for PDE8B

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Alternative Name: PDE8B

Background: Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDE1-11, PDE4, 7 and 8 selectively degrade cAMP. These enzymes are involved in many signal transduction pathways.

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process