PD-1 antibody

Catalog No. ABIN642272

The Rat anti-PD-1 antibody has been validated for FACS. It is suitable to detect PD-1 in samples from Mouse.

Quick Overview for PD-1 antibody (ABIN642272)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivity: Mouse

Host: Rat

Conjugate: This PD-1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Product Details anti-PD-1 Antibody

Specificity: DS-MB-03795 recognizes mouse CD279, a 55kD cell surface protein which is a member of the CD28/CTLA-4 family, otherwise known as Programmed Death-1 (PD-1). CD279 is expressed predominantly on activated T- and B- lymphocytes and on a subset of thymocytes. Studies suggest that CD279, an immunoinhibitory receptor, plays a critical role in peripheral tolerance induction and prevention of autoimmune disease. Two members of the B7 family, B7-H1 (PD-L1) and B7-DC (PD-L2), have been identified as the ligands for CD279. DS-MB-03795 does not block the binding of both B7-H1-Ig and B7-DC-Ig fusion proteins to PD-1 transfected BHK cells.

Characteristics: Rat Anti-Mouse CD279

Purification: Purified

Immunogen: PD-1 transferred BHK cells

Isotype: IgG2b

Application Details

Restrictions: For Research Use only

Handling

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline, pH7.4

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Alternative Name: CD279

Background: Synonyms: PD1

Pathways: Cancer Immune Checkpoints