USP6 antibody (C-Term)

Catalog No. ABIN650700

This anti-USP6 antibody is a Rabbit Polyclonal antibody detecting USP6 in WB and FACS. Suitable for Human.

Quick Overview for USP6 antibody (C-Term) (ABIN650700)

Target: USP6 (Ubiquitin Specific Peptidase 6 (USP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP6 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB4277

Product Details anti-USP6 Antibody

Binding Specificity: AA 1280-1310, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This USP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1280-1310 amino acids from the C-terminal region of human USP6.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for USP6

Target: USP6 (Ubiquitin Specific Peptidase 6 (USP6))

Alternative Name: USP6

Background: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Molecular Weight: 158658

Gene ID: 9098

NCBI Accession: NP_004496

UniProt: P35125