ILK antibody (pSer343)

Catalog No. ABIN650820

This anti-ILK antibody is a Rabbit Polyclonal antibody detecting ILK in DB. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for ILK antibody (pSer343) (ABIN650820)

Target: ILK (Integrin-Linked Kinase (ILK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ILK antibody is un-conjugated

Application: Dot Blot (DB)

Clone: RB13896

Product Details anti-ILK Antibody

Binding Specificity: pSer343

Predicted Reactivity: B, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ILK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S343 of human ILK.

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-ILK antibody (ABIN650820)

Brooker, Bond, Peng, Kessler: "β1-integrin restricts astrocytic differentiation of adult hippocampal neural stem cells." in: Glia, Vol. 64, Issue 7, pp. 1235-51, (2018) (PubMed).

Srikanth, Das, Berns, Kim, Stupp, Kessler: "Nanofiber-mediated inhibition of focal adhesion kinase sensitizes glioma stemlike cells to epidermal growth factor receptor inhibition." in: Neuro-oncology, Vol. 15, Issue 3, pp. 319-29, (2013) (PubMed).

Target Details for ILK

Target: ILK (Integrin-Linked Kinase (ILK))

Alternative Name: ILK

Background: Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. ILK is a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction.

Molecular Weight: 51419

Gene ID: 3611

NCBI Accession: NP_001014794, NP_001014795, NP_001265370, NP_004508

UniProt: Q13418

Pathways: Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Smooth Muscle Cell Migration