SLAMF7 antibody (AA 58-85)

Catalog No. ABIN651870

This anti-SLAMF7 antibody is a Rabbit Polyclonal antibody detecting SLAMF7 in WB. Suitable for Human.

Quick Overview for SLAMF7 antibody (AA 58-85) (ABIN651870)

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLAMF7 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB22341

Product Details anti-SLAMF7 Antibody

Binding Specificity: AA 58-85

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SLAMF7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-85 amino acids from the Central region of human SLAMF7.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for SLAMF7

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Alternative Name: SLAMF7

Background: SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.

Molecular Weight: 37421

Gene ID: 57823

NCBI Accession: NP_067004

UniProt: Q9NQ25