MYD88 antibody (AA 136-164)

Catalog No. ABIN652460

The Rabbit Polyclonal anti-MYD88 antibody has been validated for WB, FACS and IHC (p). It is suitable to detect MYD88 in samples from Human and Mouse. There are 2+ publications available.

Quick Overview for MYD88 antibody (AA 136-164) (ABIN652460)

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYD88 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB21010

Product Details anti-MYD88 Antibody

Binding Specificity: AA 136-164

Predicted Reactivity: Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MyD88 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from the Central region of human MyD88.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. IHC-P: 1:10~50. FC: 0.059027777777778

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MYD88 antibody (ABIN652460)

Deng, Yuan, Guo, Zhu, Pan, Liu: "Efficacy of atorvastatin on hippocampal neuronal damage caused by chronic intermittent hypoxia: involving TLR4 and its downstream signaling pathway." in: Respiratory physiology & neurobiology, (2015) (PubMed).

Ren, Sun, Deng, Zhang, Wu, Wei, Mani, Dou, Wang: "The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 309, Issue 7, pp. G517-27, (2015) (PubMed).

Target Details for MYD88

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Alternative Name: MyD88

Background: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. It acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response and increases IL-8 transcription. It may be involved in myeloid differentiation.

Molecular Weight: 33233

Gene ID: 4615

NCBI Accession: NP_001166037, NP_001166039, NP_001166040, NP_002459

UniProt: Q99836

Pathways: NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades