LMX1B antibody (AA 175-202)

Catalog No. ABIN652882

This Rabbit Polyclonal antibody specifically detects LMX1B in WB and IHC (p). It exhibits reactivity toward Human and Mouse and has been mentioned in 2+ publications.

Quick Overview for LMX1B antibody (AA 175-202) (ABIN652882)

Target: LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LMX1B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB21468

Product Details anti-LMX1B Antibody

Binding Specificity: AA 175-202

Predicted Reactivity: C, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LMX1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-202 amino acids from the Central region of human LMX1B.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-LMX1B antibody (ABIN652882)

Doucet-Beaupré, Gilbert, Profes, Chabrat, Pacelli, Giguère, Rioux, Charest, Deng, Laguna, Ericson, Perlmann, Ang, Cicchetti, Parent, Trudeau, Lévesque: "Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 30, pp. E4387-96, (2018) (PubMed).

Laguna, Schintu, Nobre, Alvarsson, Volakakis, Jacobsen, Gómez-Galán, Sopova, Joodmardi, Yoshitake, Deng, Kehr, Ericson, Svenningsson, Shupliakov, Perlmann: "Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease." in: Nature neuroscience, Vol. 18, Issue 6, pp. 826-35, (2015) (PubMed).

Target Details for LMX1B

Target: LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

Alternative Name: LMX1B

Background: LMX1B is required for the normal development of the dopaminergic system. Loss of dopaminergic neurons is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons play an important role in the control of multiple brain functions including voluntary movement alongside an array of behavioral processes such as mood, reward, addiction, and stress. Lmx1b is one of several transcription factors involved in the generation of dopaminergic neurons in the brain.

Molecular Weight: 44917

Gene ID: 4010

NCBI Accession: NP_001167618, NP_002307

UniProt: O60663

Pathways: Dopaminergic Neurogenesis