GSTa2 antibody (N-Term)

Catalog No. ABIN653362

This Rabbit Polyclonal antibody specifically detects GSTa2 in WB and IHC (p). It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for GSTa2 antibody (N-Term) (ABIN653362)

Target: GSTa2 (Glutathione S-Transferase alpha 2 (GSTa2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSTa2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB24006

Product Details anti-GSTa2 Antibody

Binding Specificity: AA 1-30, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GSTA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GSTA2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-GSTa2 antibody (ABIN653362)

Huang, Guo, Li, Zhang: "Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes." in: Scientific reports, Vol. 7, pp. 40716, (2018) (PubMed).

Li, Yuan, Li, Liu, Hua, Lu, Zhang: "Direct differentiation of homogeneous human adipose stem cells into functional hepatocytes by mimicking liver embryogenesis." in: Journal of cellular physiology, Vol. 229, Issue 6, pp. 801-12, (2014) (PubMed).

Target Details for GSTa2

Target: GSTa2 (Glutathione S-Transferase alpha 2 (GSTa2))

Alternative Name: GSTA2

Background: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Molecular Weight: 25664

Gene ID: 2939

NCBI Accession: NP_000837

UniProt: P09210