CHMP4B antibody (N-Term)

Catalog No. ABIN653481

This anti-CHMP4B antibody is a Rabbit Polyclonal antibody detecting CHMP4B in WB, FACS and IHC (p). Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for CHMP4B antibody (N-Term) (ABIN653481)

Target: CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP4B antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB24088

Product Details anti-CHMP4B Antibody

Binding Specificity: AA 51-79, N-Term

Predicted Reactivity: C, Zf, M, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHMP4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-79 amino acids from the N-terminal region of human CHMP4B.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-CHMP4B antibody (ABIN653481)

Hu, Jiang, Chen, Wei, Zhang, Zhao, Ni, Lu, Wan: "High CHMP4B expression is associated with accelerated cell proliferation and resistance to doxorubicin in hepatocellular carcinoma." in: Tumour biology, Vol. 36, Issue 4, pp. 2569-81, (2015) (PubMed).

Target Details for CHMP4B

Target: CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))

Alternative Name: CHMP4B

Background: CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies.

Molecular Weight: 24950

Gene ID: 128866

NCBI Accession: NP_789782

UniProt: Q9H444