KDM4C antibody (C-Term)

Catalog No. ABIN655391

The Rabbit Polyclonal anti-KDM4C antibody has been validated for WB and FACS. It is suitable to detect KDM4C in samples from Human and Mouse.

Quick Overview for KDM4C antibody (C-Term) (ABIN655391)

Target: KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM4C antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB10796

Product Details anti-KDM4C Antibody

Binding Specificity: AA 1023-1056, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This JMJD2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1023-1056 amino acids from the C-terminal region of human JMJD2C.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. FC: 1:25. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for KDM4C

Target: KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))

Alternative Name: JMJD2C

Background: This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.

Molecular Weight: 119982

Gene ID: 23081

NCBI Accession: NP_001140166, NP_001140167, NP_001140168, NP_055876

UniProt: Q9H3R0

Pathways: Nuclear Hormone Receptor Binding, Warburg Effect