TNFSF15 antibody (AA 148-175)

Catalog No. ABIN655822

This Rabbit Polyclonal antibody specifically detects TNFSF15 in WB, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for TNFSF15 antibody (AA 148-175) (ABIN655822)

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFSF15 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: RB21818

Product Details anti-TNFSF15 Antibody

Binding Specificity: AA 148-175

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TNFSF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-175 amino acids from the Central region of human TNFSF15.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for TNFSF15

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Alternative Name: TNFSF15

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined. [provided by RefSeq].

Molecular Weight: 28087

Gene ID: 9966

NCBI Accession: NP_001191273, NP_005109

UniProt: O95150

Pathways: Positive Regulation of Endopeptidase Activity, Autophagy