PCDHGA8 antibody (C-Term)

Catalog No. ABIN655955

The Rabbit Polyclonal anti-PCDHGA8 antibody has been validated for WB, IF and IHC (p). It is suitable to detect PCDHGA8 in samples from Human.

Quick Overview for PCDHGA8 antibody (C-Term) (ABIN655955)

Target: PCDHGA8 (Protocadherin gamma Subfamily A, 8 (PCDHGA8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHGA8 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB31662

Product Details anti-PCDHGA8 Antibody

Binding Specificity: AA 781-808, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PCDHGA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 781-808 amino acids from the C-terminal region of human PCDHGA8.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for PCDHGA8

Target: PCDHGA8 (Protocadherin gamma Subfamily A, 8 (PCDHGA8))

Alternative Name: PCDHGA8

Background: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Molecular Weight: 101480

Gene ID: 9708

NCBI Accession: NP_054723, NP_114477

UniProt: Q9Y5G5