Tetraspanin 7 antibody (FITC)

Catalog No. ABIN6559827

Product Details anti-Tetraspanin 7 Antibody (FITC)

Target: Tetraspanin 7 (TSPAN7)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Tetraspanin 7 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Purpose: Anti-Hu CD231 FITC

Specificity: The mouse monoclonal antibody B2D recognizes an extracellular epitope of CD231 (TALLA-1, tetraspanin 7), a transmembrane glycoprotein expressed in neuronal tissue and T-ALL.

Cross-Reactivity (Details): Human, Other not determined

Purification: Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Human T-ALL cell line THP-6

Clone: B2D

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for Tetraspanin 7

Target: Tetraspanin 7 (TSPAN7)

Alternative Name: CD231 (TSPAN7 Products)

Background: Tetraspanin 7,CD231 (TALLA-1, T-ALL-asociated antigen 1), also known as tetraspanin 7, is a 150 kDa (under reducing conditions 32-45 kDa) transmembrane glycoprotein of tetraspanin family, expressed in T-type acute lymphoblastic leukemia, neuroblastoma, and neuronal tissue. Mutations of CD231 gene are associated with X-linked mental retardation, Huntington´s chorea, and myotonic dystrophy. CD231 interacts with integrins and may have a role in the control of neurite outgrowth. Antibodies to CD231 are important for detection of T-ALL and are potential targets of its treatment.,TSPAN7, TALLA-1, MXS1, MRX58, TM4SF2

Gene ID: 7102

UniProt: P41732