Tetraspanin 7 (TSPAN7) antibody

Details for Product No. ABIN6559816
Antigen
Reactivity
Human
66
22
13
Host
Mouse
62
6
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
7
6
5
3
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
46
38
20
7
6
4
3
1
1
1
Options
Immunogen Human T-ALL cell line THP-6
Clone B2D
Isotype IgG1
Specificity The mouse monoclonal antibody B2D recognizes CD231 (TALLA-1, tetraspanin 7), a transmembrane glycoprotein expressed in neuronal tissue and T-ALL.
Cross-Reactivity (Details) Human, Other not determined
Purification Purified from hybridoma culture supernatant by protein-A affinity chromatography.
Purity > 95 % (by SDS-PAGE)
Antigen
Alternative Name CD231 (TSPAN7 Antibody Abstract)
Background CD231 (TALLA-1, T-ALL-asociated antigen 1), also known as tetraspanin 7, is a 150 kDa (under reducing conditions 32-45 kDa) transmembrane glycoprotein of tetraspanin family, expressed in T-type acute lymphoblastic leukemia, neuroblastoma, and neuronal tissue. Mutations of CD231 gene are associated with X-linked mental retardation, Huntington´s chorea, and myotonic dystrophy. CD231 interacts with integrins and may have a role in the control of neurite outgrowth. Antibodies to CD231 are important for detection of T-ALL and are potential targets of its treatment.
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C