SESN3 antibody (AA 320-347)

Catalog No. ABIN2845697

This anti-SESN3 antibody is a Rabbit Polyclonal antibody detecting SESN3 in WB and IHC (p). Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for SESN3 antibody (AA 320-347) (ABIN2845697)

Target: SESN3 (Sestrin 3 (SESN3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SESN3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB18605

Product Details anti-SESN3 Antibody

Binding Specificity: AA 320-347

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Sestrin-3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-347 amino acids from the Central region of human Sestrin-3.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:2000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Sestrin-3 Antibody (Center Y335) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-SESN3 antibody (ABIN2845697)

Kimball, Ravi, Gordon, Dennis, Jefferson: "Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet." in: The Journal of nutrition, Vol. 145, Issue 11, pp. 2496-502, (2015) (PubMed).

Ye, Palm, Peng, King, Lindsten, Li, Koumenis, Thompson: "GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2." in: Genes & development, Vol. 29, Issue 22, pp. 2331-6, (2015) (PubMed).

Target Details for SESN3

Target: SESN3 (Sestrin 3 (SESN3))

Alternative Name: Sestrin-3

Background: Sestrins form a small family of redox enzymes which regulate accumulation of Reactive Oxygen Species. They protect cells and their DNA against oxidative damage and regulate cell growth and viability. These genes are often deregulated in cancers and their inactivation accelerates the growth of model tumors in mice.

Molecular Weight: 57291

Gene ID: 143686

NCBI Accession: NP_653266

UniProt: P58005