BCL2 antibody (B-Cell CLL/lymphoma 2)

Details for Product anti-BCL2 Antibody No. ABIN6566500
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
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11
4
3
3
3
2
1
1
Host
Rabbit
652
390
9
6
2
Clonality
Polyclonal
Conjugate
This BCL2 antibody is un-conjugated
56
46
29
26
22
15
14
14
14
14
14
14
7
7
7
7
7
7
7
7
7
7
7
7
7
6
6
6
6
6
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
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268
184
155
120
79
54
40
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26
23
17
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15
9
3
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1
1
1
1
1
Options
Immunogen A synthetic peptide of human BCL2
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name BCL2 (BCL2 Antibody Abstract)
Background

Synonyms: Apoptosis regulator Bcl 2,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl2,AW986256,B cell CLL/lymphoma 2,B cell leukemia/lymphoma 2,Bcl-2,Bcl2,BCL2,C430015F12Rik,D630044D05Rik,D830018M01Rik,Leukemia/lymphoma,B-cell,2,Oncogene B-cell leukemia 2,PPP1R50,Protein phosphatase 1,regulatory subunit 50

Background: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.

Molecular Weight

Observed_MW: 26kDa

Calculated_MW: 22kDa/26kDa

Gene ID 596
UniProt P10415
Pathways MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:100
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-B-Cell CLL/lymphoma 2 (BCL2) antibody (ABIN6566500) Western blot analysis of extracts of various cell lines, using BCL2 antibody.
Image no. 2 for anti-B-Cell CLL/lymphoma 2 (BCL2) antibody (ABIN6566500) Immunohistochemistry of paraffin-embedded human liver cancer using BCL2 antibody.
Image no. 3 for anti-B-Cell CLL/lymphoma 2 (BCL2) antibody (ABIN6566500) Immunohistochemistry of paraffin-embedded human gastric cancer using BCL2 antibody.