Lamin A/C antibody (LMNA)

Details for Product anti-LMNA Antibody No. ABIN6566533
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This Lamin A/C antibody is un-conjugated
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Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
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Options
Immunogen Recombinant protein of human Lamin A/C
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name LMNA (LMNA Antibody Abstract)
Background

Synonyms: 70 kDa lamin,Cardiomyopathy dilated 1A (autosomal dominant),CDCD1,CDDC,CMD1A,CMT2B1,EMD2,FPL,FPLD,FPLD2,HGPS,IDC,Lamin A,Lamin A/C,Lamin A/C like 1,Lamin,Lamin C,Lamin-A/C,LDP1,LFP,LGMD1B,Limb girdle muscular dystrophy 1B (autosomal dominant),LMN 1,LMN A,LMN C,LMN1,LMNA,LMNA,LMNC,LMNL1,Prelamin A/C,PRO1,Renal carcinoma antigen NY REN 32,Renal carcinoma antigen NY-REN-32,Renal carcinoma antigen NYREN32

Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Molecular Weight

Observed_MW: 74kDa

Calculated_MW: 62-74kDa

Gene ID 4000
UniProt P02545
Pathways Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Lamin A/C (LMNA) antibody (ABIN6566533) Western blot analysis of extracts of various cell lines, using Lamin A/C antibody.
Image no. 2 for anti-Lamin A/C (LMNA) antibody (ABIN6566533) Immunofluorescence analysis of HeLa cells using Lamin A/C antibody.
Image no. 3 for anti-Lamin A/C (LMNA) antibody (ABIN6566533) Immunohistochemistry of paraffin-embedded human kidney cancer using Lamin A/C antibody.
Image no. 4 for anti-Lamin A/C (LMNA) antibody (ABIN6566533) Immunohistochemistry of paraffin-embedded mouse kidney using Lamin A/C antibody.