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Lamin A/C antibody

LMNA Reactivity: Human, Mouse, Rat WB, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6566533
  • Target See all Lamin A/C (LMNA) Antibodies
    Lamin A/C (LMNA)
    Reactivity
    • 134
    • 77
    • 74
    • 26
    • 15
    • 12
    • 8
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 99
    • 44
    • 2
    • 1
    Rabbit
    Clonality
    • 101
    • 45
    Polyclonal
    Conjugate
    • 109
    • 9
    • 8
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Lamin A/C antibody is un-conjugated
    Application
    • 116
    • 54
    • 52
    • 46
    • 31
    • 29
    • 28
    • 16
    • 12
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human Lamin C (NP_005563.1).
    Isotype
    IgG
    Top Product
    Discover our top product LMNA Primary Antibody
  • Application Notes
    WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Lamin A/C (LMNA)
    Alternative Name
    Lamin A/C (LMNA Products)
    Background
    The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
    Molecular Weight

    Observed_MW: 74kDa

    Calculated_MW: 62-74kDa

    Gene ID
    4000
    UniProt
    P02545
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
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