PIK3CA antibody (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide)

Details for Product anti-PIK3CA Antibody No. ABIN6566545
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
146
91
46
2
1
Host
Rabbit
144
19
8
1
Clonality
Polyclonal
Conjugate
This PIK3CA antibody is un-conjugated
11
9
8
6
6
6
3
3
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
118
77
73
22
13
13
8
4
4
2
2
1
1
Options
Immunogen Recombinant protein of human PIK3CA
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name PI 3 kinase p110 alpha (PIK3CA Antibody Abstract)
Background

Synonyms: 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,5-bisphosphate 3-kinase catalytic subunit alpha isoform,caPI3K,CLOVE,CWS5,MCAP,MCM,MCMTC,MGC142161,MGC142163,p110 alpha,p110alpha,Phosphatidylinositol 3 kinase catalytic alpha polypeptide,Phosphatidylinositol 3 kinase catalytic 110 KD alpha,Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha,Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform,Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha,Phosphatidylinositol-4,Phosphoinositide 3 kinase catalytic alpha polypeptide,PI3 kinase p110 subunit alpha,PI3-kinase subunit alpha,PI3K,PI3K-alpha,PI3KC A,PIK3C A,Pik3ca,PK3CA,PK3CA,PtdIns 3 kinase p110,PtdIns-3-kinase subunit alpha,PtdIns-3-kinase subunit p110-alpha,Serine/threonine protein kinase PIK3CA

Background: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22.

Molecular Weight

Observed_MW: 115-120kDa

Calculated_MW: 124kDa

Gene ID 5290
UniProt P42336
Pathways PI3K-Akt Signaling, RTK Signaling, TCR Signaling, AMPK Signaling, Interferon-gamma Pathway, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, VEGF Signaling
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:100
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) antibody (ABIN6566545) Immunohistochemistry of paraffin-embedded rat kidney using PIK3CA antibody.
Image no. 2 for anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) antibody (ABIN6566545) Western blot analysis of extracts of various cell lines, using PIK3CA antibody.
Image no. 3 for anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) antibody (ABIN6566545) Immunohistochemistry of paraffin-embedded human prostate using PIK3CA antibody.