Synonyms: 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,5-bisphosphate 3-kinase catalytic subunit alpha isoform,caPI3K,CLOVE,CWS5,MCAP,MCM,MCMTC,MGC142161,MGC142163,p110 alpha,p110alpha,Phosphatidylinositol 3 kinase catalytic alpha polypeptide,Phosphatidylinositol 3 kinase catalytic 110 KD alpha,Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha,Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform,Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha,Phosphatidylinositol-4,Phosphoinositide 3 kinase catalytic alpha polypeptide,PI3 kinase p110 subunit alpha,PI3-kinase subunit alpha,PI3K,PI3K-alpha,PI3KC A,PIK3C A,Pik3ca,PK3CA,PK3CA,PtdIns 3 kinase p110,PtdIns-3-kinase subunit alpha,PtdIns-3-kinase subunit p110-alpha,Serine/threonine protein kinase PIK3CA
Background: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22.