STAT5B antibody (Signal Transducer and Activator of Transcription 5B)

Details for Product anti-STAT5B Antibody No. ABIN6566554
Antigen
Reactivity
Human, Rat (Rattus)
230
133
121
15
14
14
11
9
7
6
6
4
2
2
2
1
Host
Rabbit
187
51
Clonality
Polyclonal
Conjugate
This STAT5B antibody is un-conjugated
8
5
5
5
5
5
5
5
5
2
2
2
2
2
2
2
2
Application
Immunofluorescence (IF), Western Blotting (WB)
175
94
89
40
26
26
14
7
6
4
3
2
2
2
1
1
1
1
1
Options
Immunogen Recombinant protein of human STAT5B
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name STAT5B (STAT5B Antibody Abstract)
Background

Synonyms: Signal transducer and activator of transcription 5B,STA5B,STAT5,Stat5b,Transcription factor STAT5B

Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Molecular Weight

Observed_MW: 95kDa

Calculated_MW: 89kDa

Gene ID 6777
UniProt P51692
Pathways JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
Application Notes WB 1:500 - 1:2000 IF 1:20 - 1:50
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Signal Transducer and Activator of Transcription 5B (STAT5B) antibody (ABIN6566554) Western blot analysis of extracts of various cell lines, using STAT5B antibody.
Image no. 2 for anti-Signal Transducer and Activator of Transcription 5B (STAT5B) antibody (ABIN6566554) Immunofluorescence analysis of HeLa cells using STAT5B antibody.