P27 antibody

Details for Product No. ABIN6566565
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
51
27
25
7
1
1
Host
Rabbit
42
11
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
33
31
16
12
8
6
6
1
Options
Immunogen Recombinant protein of human CDKN1B
Isotype IgG
Purification Affinity purification
Antigen
Background

Synonyms: AA408329,AI843786,Cdki1b,CDKN 1B,CDKN 4,CDKN1B,CDKN4,CDN1B,Cyclin Dependent Kinase Inhibitor 1B,Cyclin dependent kinase inhibitor p27,Cyclin-dependent kinase inhibitor 1B (p27,Kip1),Cyclin-dependent kinase inhibitor 1B,Cyclin-dependent kinase inhibitor p27,Cyclin-dependent kinase inhibitor p27 Kip1,KIP 1,KIP1,MEN1B,MEN4,OTTHUMP00000195098,OTTHUMP00000195099,p27,p27 Kip1,P27-like cyclin-dependent kinase inhibitor,p27Kip1

Background: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

Molecular Weight

Calculated_MW: 22kDa

Gene ID 1027
UniProt P46527
Application Notes IHC 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-P27 antibody (ABIN6566565) Immunohistochemistry of paraffin-embedded mouse kidney using CDKN1B Antibody.
Image no. 2 for anti-P27 antibody (ABIN6566565) Immunohistochemistry of paraffin-embedded rat brain using CDKN1B Antibody.